Table of Contents

Foreword.- Preface.- 1 Anatomophysiology of the neuroendocrine system: Embryology, Anatomy – Histology – Citology, Physiology.- 2 Epidemiology: Risk factors.- 3 Classification: WHO (grading), site.- 4 Pathology: Anatomic pathology, Immunohistochemistry. – 5 Molecular biology: Molecular pathways, Oncogenes, Suppressor genes.- 6 Clinical presentations: Non functioning NETs.- 7 Clinical presentations: Hormone releasing NETs (Carcinoid syndrome, Insulinoma, Glucagonoma, VIPoma, Somatostatinoma, Others, GRFoma.- 8 MEN 1, MEN 2am, MEN 2b, and Others (TSC, VHL, NF1).- 9 Diagnosis: (Serum biomarkers, Endoscopy, Imaging (US, CT Scan, MRI, Angiography, Scintigraphy, PET).- 10 Staging: TNM.- 11 Surgical treatment: Gastric NETs, Duodenum NETs, Jejuno-ileal NETs, Colorectal NETs, Pancreatic NETs (Head, Body-tail), Adrenal NETs.- 12 Non surgical treatments: Chemotherapy, Hormonal syndrome treatment, Targeted therapies, IFN.- 13 Metastatic disease: Liver metastases (Surgery, RF ablation and cryoablation, Arterial chemoembolization).- 14 Systemic therapy (Somatostatina analogs, Alpha IFN, Cytotoxic chemotherapy, Peptide receptor radiotherapy, VEGF inhibitors, mTOR inhibitors.- 15 Flow-charts.

About the Author

Massimo Carlini is Director of the Department of  General Surgery at the S. Eugenio Hospital in Rome. He graduated in Medicine and Surgery (cum laude) from the Sapienza University of Rome in 1982 and subsequently specialized in General Surgery, Oncologic Surgery, and Emergency Surgery. Adjunct Professor at the University of Rome, Italy and a Tutor and Teacher at the SIC and ACOI Special Schools of Minimally Invasive Surgery. He is a Councillor in the American College of Surgeons - Italy Chapter and in the Italian Society of Surgery. He is Vice President of the Roman Academy of Surgery and Regional Delegate in the Italian Society of Emergency Surgery too. Professor Carlini is the author of more than 200 scientific publications and more than 70 videos of open and minimally invasive surgical techniques. He has performed over 15.000 surgical procedures, mainly minimally invasive, for esophagogastric, hepatobiliary, pancreatic and colorectal diseases.