Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation.
Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.
Foreword Preface Contributors Part I: Animal Care and Surgery Chapter 1: Animal Protocol Laurel D. Schantz Chapter 2: Anesthesia and Analgesia for Research Animals Andrew R. Blickman and Lisa J. Brossia Chapter 3: Rodent Surgical Procedures and Tissue Collection Robert Ayer, Julian Cahill, Takashi Sugawara, Vikram Jadhav and John H. Zhang Chapter 4: Brain Monitoring Julian Cahill and John H. Zhang Chapter 5: Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies Aaron H. Puckett, Christine D. Nunn and Stephen M. Onifer Part II: Cerebral Ischemic Animal Models Section I: Global Cerebral Ischemic Models Chapter 6: Four-Vessel Occlusion Model in Rats Ping Deng and Zao C. Xu Chapter 7: Rat Model of Global Cerebral Ischemia: The Two-vessel Occlusion (2VO) Model of Forebrain Ischemia Ami P. Raval, Chunli Liu and Bingren R. Hu Chapter 8: Asphyxial Cardiac Arrest Clifton W. Callaway and Eric S. Logue Chapter 9: Rodent Model of Pediatric Asphyxial Cardiac Arrest Mioara D. Manole, Henry L. Alexander, Robert W. Hickey and Robert S. B. Clark Chapter 10: Transient Global Cerebral Ischemia Model in Mice Kuniyasu Niizuma, Hidenori Endo, Chikako Nito, D. Jeannie Myer, Gab Seok Kim, Teiji Tominaga and Pak H. Chan Section II: Focal Cerebral Ischemic Models Chapter 11: Transient Middle Cerebral Artery Occlusion Model in Rodents Ying Mao, Wei Zhu and Guo-Yuan Yang Chapter 12: Three-vessel Middle Cerebral Artery Occlusion Model T.N. Lin, S.T. Chen, Y.Y. He, W.M. Cheung and Chung Y. Hsu Chapter 13: A Thromboembolic Rat Model of Focal Cerebral Ischemia and Reperfusion with tPA Yoshihiro Murata, Xiaoying Wang and Eng H. Lo Chapter 14: Targeted Occlusion to Surface and Deep Vessels in Neocortex via Linear and Nonlinear Optical Absorption David Kleinfeld, Beth Friedman, Patrick D. Lyden, and Andy Y. Shih Chapter 15: Middle Cerebral Artery Occlusion Suture Model for Mice Feng Zhang, Steven H. Graham and Jun Chen Chapter 16: Intraluminal Middle Cerebral Artery Occlusion Model in Mice Masaya Oda, Taku Sugawara, Kohei Kokubun, Kazuo Mizoi and Hiroyuki Kinouchi Chapter 17: Cerebral Hypoxia-Ischemia Model in Adult Mice Faisal Adhami and Chia-Yi Kuan Section III: Neonatal Hypoxia-Ischemia Chapter 18: Cerebral Hypoxia-Ischemia in Neonatal Rats or Mice: A Model of Perinatal Brain Injury Changlian Zhu, Xiaoyang Wang and Klas Blomgren Chapter 19: Cerebral Palsy Model of Uterine Ischemia in Pregnant Rabbits Xinhai Ji, Matthew Derrick and Sidhartha Tan Chapter 20: A Model of Neonatal Focal Cerebral Ischemia-Reperfusion Zinaida S. Vexler and Donna M. Ferriero Part III: Cerebral Hemorrhage Animal Models Section I: Subarachnoid Hemorrhage Chapter 21: Monofilament Perforation Subarachnoid Hemorrhage Rat Model Julian Cahill and John H. Zhang Chapter 22: Blood Injection Subarachnoid Hemorrhage Rat Model Hartmut Vatter, Erdem Gueresir and Volker Seifert Chapter 23: Filament Perforation Subarachnoid Hemorrhage Mouse Model Hideyuki Kamii and Teiji Tominaga Chapter 24: Blood Injection Subarachnoid Hemorrhage Mouse Model Tarkan Calisaneller, Chih-L
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Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation.
Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.
Foreword Preface Contributors Part I: Animal Care and Surgery Chapter 1: Animal Protocol Laurel D. Schantz Chapter 2: Anesthesia and Analgesia for Research Animals Andrew R. Blickman and Lisa J. Brossia Chapter 3: Rodent Surgical Procedures and Tissue Collection Robert Ayer, Julian Cahill, Takashi Sugawara, Vikram Jadhav and John H. Zhang Chapter 4: Brain Monitoring Julian Cahill and John H. Zhang Chapter 5: Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies Aaron H. Puckett, Christine D. Nunn and Stephen M. Onifer Part II: Cerebral Ischemic Animal Models Section I: Global Cerebral Ischemic Models Chapter 6: Four-Vessel Occlusion Model in Rats Ping Deng and Zao C. Xu Chapter 7: Rat Model of Global Cerebral Ischemia: The Two-vessel Occlusion (2VO) Model of Forebrain Ischemia Ami P. Raval, Chunli Liu and Bingren R. Hu Chapter 8: Asphyxial Cardiac Arrest Clifton W. Callaway and Eric S. Logue Chapter 9: Rodent Model of Pediatric Asphyxial Cardiac Arrest Mioara D. Manole, Henry L. Alexander, Robert W. Hickey and Robert S. B. Clark Chapter 10: Transient Global Cerebral Ischemia Model in Mice Kuniyasu Niizuma, Hidenori Endo, Chikako Nito, D. Jeannie Myer, Gab Seok Kim, Teiji Tominaga and Pak H. Chan Section II: Focal Cerebral Ischemic Models Chapter 11: Transient Middle Cerebral Artery Occlusion Model in Rodents Ying Mao, Wei Zhu and Guo-Yuan Yang Chapter 12: Three-vessel Middle Cerebral Artery Occlusion Model T.N. Lin, S.T. Chen, Y.Y. He, W.M. Cheung and Chung Y. Hsu Chapter 13: A Thromboembolic Rat Model of Focal Cerebral Ischemia and Reperfusion with tPA Yoshihiro Murata, Xiaoying Wang and Eng H. Lo Chapter 14: Targeted Occlusion to Surface and Deep Vessels in Neocortex via Linear and Nonlinear Optical Absorption David Kleinfeld, Beth Friedman, Patrick D. Lyden, and Andy Y. Shih Chapter 15: Middle Cerebral Artery Occlusion Suture Model for Mice Feng Zhang, Steven H. Graham and Jun Chen Chapter 16: Intraluminal Middle Cerebral Artery Occlusion Model in Mice Masaya Oda, Taku Sugawara, Kohei Kokubun, Kazuo Mizoi and Hiroyuki Kinouchi Chapter 17: Cerebral Hypoxia-Ischemia Model in Adult Mice Faisal Adhami and Chia-Yi Kuan Section III: Neonatal Hypoxia-Ischemia Chapter 18: Cerebral Hypoxia-Ischemia in Neonatal Rats or Mice: A Model of Perinatal Brain Injury Changlian Zhu, Xiaoyang Wang and Klas Blomgren Chapter 19: Cerebral Palsy Model of Uterine Ischemia in Pregnant Rabbits Xinhai Ji, Matthew Derrick and Sidhartha Tan Chapter 20: A Model of Neonatal Focal Cerebral Ischemia-Reperfusion Zinaida S. Vexler and Donna M. Ferriero Part III: Cerebral Hemorrhage Animal Models Section I: Subarachnoid Hemorrhage Chapter 21: Monofilament Perforation Subarachnoid Hemorrhage Rat Model Julian Cahill and John H. Zhang Chapter 22: Blood Injection Subarachnoid Hemorrhage Rat Model Hartmut Vatter, Erdem Gueresir and Volker Seifert Chapter 23: Filament Perforation Subarachnoid Hemorrhage Mouse Model Hideyuki Kamii and Teiji Tominaga Chapter 24: Blood Injection Subarachnoid Hemorrhage Mouse Model Tarkan Calisaneller, Chih-L
Show moreAnimal Care and Surgery.- Animal Protocol.- Anesthesia and Analgesia for Research Animals.- Rodent Surgical Procedures and Tissue Collection.- Brain Monitoring.- Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies.- Cerebral Ischemic Animal Models.- Four-Vessel Occlusion Model in Rats.- Rat Model of Global Cerebral Ischemia: The Two-Vessel Occlusion (2VO) Model of Forebrain Ischemia.- Asphyxial Cardiac Arrest.- Rodent Model of Pediatric Asphyxial Cardiac Arrest.- Transient Global Cerebral Ischemia Model in Mice.- Transient Middle Cerebral Artery Occlusion Model in Rodents.- Three-Vessel Middle Cerebral Artery Occlusion Model.- A Thromboembolic Rat Model of Focal Cerebral Ischemia and Reperfusion with tPA.- Targeted Occlusion to Surface and Deep Vessels in Neocortex via Linear and Nonlinear Optical Absorption.- Middle Cerebral Artery Occlusion Suture Model for Mice.- Intraluminal Middle Cerebral Artery Occlusion Model in Mice.- Cerebral Hypoxia—IschemiaModel in Adult Mice.- Cerebral Hypoxia—Ischemia in Neonatal Rats or Mice: A Model of Perinatal Brain Injury.- Cerebral Palsy Model of Uterine Ischemia in Pregnant Rabbits.- Model of Neonatal Focal Cerebral Ischemia-Reperfusion.- Cerebral Hemorrhage Animal Models.- Monofilament Perforation Subarachnoid Hemorrhage Rat Model.- Blood Injection Subarachnoid Hemorrhage Rat Model.- Filament Perforation Subarachnoid Hemorrhage: Mouse Model.- Blood Injection Subarachnoid Hemorrhage Mouse Model.- Blood Injection Cerebral Vasospasm Rabbit Model.- Double Blood-Injection Cerebral Vasospasm Canine Model.- Nonhuman Primate Blood-Clot Placement Cerebral Vasospasm Model.- Blood Injection Intracerebral Hemorrhage Rat Model.- Bacterial Collagenase Injection Intracerebral Hemorrhage Rat Model.- Blood Injection Intracerebral Hemorrhage Mouse Model.- Blood Injection Intracerebral Hemorrhage Pig Model.- Traumatic CNS Injury Animal Models.- Fluid Percussion Injury Model.- Controlled Cortical Impact Injury Model.- Marmarou Weight Drop Injury Model.- MASCIS Spinal Cord Contusion Model.- Infinite Horizon Spinal Cord Contusion Model.- The Ohio State University ESCID Spinal Cord Contusion Model.- Acute Clip Impact-Compression Model.- Experimental Laceration Spinal Cord Injury Model.- Rodent Spinal Cord Demyelination Models.- Spinal Cord Lateral Hemisection and Implantation of Guidance Channels.- Spinal Root Avulsion and Repair Model.
From the reviews: "In this book, the editors have provided detailed discussions on numerous models of acute neurologic injury ! . an invaluable resource to anyone starting out in the neuroinjury field or to experienced individuals who require an update in terms of animal modeling. ! I recommend this book to ! investigators in the field of neurologic injuries, including students, basic scientists, and clinicians. I think anyone in the field of experimental or clinical neurologic disorders will find this book to be extremely helpful ! ." (American Journal of Neuroradiology, Vol. 30, March, 2009)
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