Signalling within and between cells is one of the most important aspects of modern biochemistry and cell biology. An understanding of signalling pathways is vital to a wide range of biologists, from those who are investigating the causes of cancer, to those who are concerned about the impact of environmental pollutants on the ecosystem. The way cells adapt to changing environments, and the way cell dysfunction causes disease, is underpinned by cell signalling events. Cell Signalling presents a carefully structured and highly accessible introduction to this intricate and rapidly growing field. Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms, before examining how these components come together to create signalling pathways. A focus on common components and concepts, rather than mechanistic detail, allows the reader to gain a thorough understanding of the principles that underpin cell signalling. Online Resource Centre The Online Resource Centre to accompany Cell Signalling features: For students: - Links to useful websites For registered adopters of the text: - Journal Clubs: suggested research papers and discussion questions linked to topics featured in the book - Figures from the book in electronic format for use in lectures
Signalling within and between cells is one of the most important aspects of modern biochemistry and cell biology. An understanding of signalling pathways is vital to a wide range of biologists, from those who are investigating the causes of cancer, to those who are concerned about the impact of environmental pollutants on the ecosystem. The way cells adapt to changing environments, and the way cell dysfunction causes disease, is underpinned by cell signalling events. Cell Signalling presents a carefully structured and highly accessible introduction to this intricate and rapidly growing field. Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms, before examining how these components come together to create signalling pathways. A focus on common components and concepts, rather than mechanistic detail, allows the reader to gain a thorough understanding of the principles that underpin cell signalling. Online Resource Centre The Online Resource Centre to accompany Cell Signalling features: For students: - Links to useful websites For registered adopters of the text: - Journal Clubs: suggested research papers and discussion questions linked to topics featured in the book - Figures from the book in electronic format for use in lectures
Part 1: An overview of signalling
1: Aspects of cellular signalling
2: Pathways are the key to signalling
3: A look at some of the history and techniques of cell
signalling
Part 2: Components that comprise signalling pathways
4: Extracellular signals: hormones, cytokines and growth
factors
5: Detection of extracellular signals: the role of receptors
6: Protein phosphorylation, kinases and phosphatases
7: Cyclic nucleotides, cyclases and G proteins
8: Inositol phosphate metabolism and roles of membrane lipids
9: Intracellular calcium ions: control of their concentrations and
roles in signalling
10: Reactive oxygen species, reactive nitrogen species and redox
signalling
Part 3: Selected examples of signalling pathways and events
11: Insulin and the signal transduction cascades it invokes
12: Perception of the environment
13: Signalling in development and for the regulation of gene
expression
14: Life, death and apoptosis
Part 4: Final thoughts
15: Cell signalling: importance, complexity and the future
John Hancock is Professor of Cell Signalling at the University of the West of England. He has had a long standing interest in cell signalling and redox biology, and tries to bring these together as much as possible in his research. In addition to Cell Signalling he has published several reviews on nitric oxide and reactive oxygen species, and most recently on hydrogen sulfide.
`A good overview of the key underlying concepts and principles,
allowing students to gain a solid grounding in the subject. I like
the Case Study sections which link to research findings; these
provide relevant context and help students to understand the key
message in complex scientific articles.'
Dr Andrew Chantry, University of East Anglia
`It is really the best specialist text for undergraduates on this
topic I have seen.'
Dr Fergus Doherty, University of Nottingham
`Review from previous edition: John Hancock's Cell Signalling is a
straightforward introduction to a rapidly expanding field of
biology. Its unintimidating writing style, simple and uncluttered
figures, and competitive price make it a wonderful introductory
text for undergraduates.'
Dr Laura K. Palmer, Penn State University
`Review from previous edition: Complexity and specificity are the
hallmarks of cell signalling, yet Hancock in this third edition has
gone a long way to simplify these complicated processes. His
signalling examples are clever and well-conceived, his writing
descriptive and his passion for his subject infectious ... this is
marvellous value for money and is a worthy companion to an
undergraduate/postgraduate reference library.'
John P. Phelan, Waterford Institute of Technology, Ireland in The
Biochemist
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