In the past two decades, there have been astonishing advances in our understanding of the neurobiological basis and nature of drug addiction. We now know the initial molecular sites of action, at identified receptors, of virtually all of the major drugs of abuse including cocaine, heroin, and amphetamine, as well as legal drugs such as nicotine and alcohol. We also understand the main components of a 'reward system' and its connections to major brain regions
involved in motivation and emotion, such as the amygdala, hippocampus, and prefrontal cortex. The Neurobiology of Addiction describes the latest advances in our understanding of
addiction. It brings together world class researchers to debate the nature and extent of addiction, as well as its causes, consequences, and treatment. The focus of the book is on the brain processes underlying addiction, in terms of neural systems, neurochemical basis, and molecular changes. Several types of addiction are discussed ranging from illicit drugs - cocaine, amphetamine, and heroin to legal drugs - alcohol and nicotine. In addition, it explores increasingly common behavioural
addictions such as gambling and obesity. Included are chapters on vulnerability to addiction, genetic factors, opponent motivational processes, animal models, relapse, cognitive deficits associated with
drug abuse, new pharmacological treatments, and current controversies concerning different neuropsychological theories of addiction. Throughout, it reports on cutting edge research using brain imaging, and state of the art molecular methodology.The book will make fascinating reading for students and teachers in the field of neuroscience, pharmacology and psychology, as well as experts in the field.
In the past two decades, there have been astonishing advances in our understanding of the neurobiological basis and nature of drug addiction. We now know the initial molecular sites of action, at identified receptors, of virtually all of the major drugs of abuse including cocaine, heroin, and amphetamine, as well as legal drugs such as nicotine and alcohol. We also understand the main components of a 'reward system' and its connections to major brain regions
involved in motivation and emotion, such as the amygdala, hippocampus, and prefrontal cortex. The Neurobiology of Addiction describes the latest advances in our understanding of
addiction. It brings together world class researchers to debate the nature and extent of addiction, as well as its causes, consequences, and treatment. The focus of the book is on the brain processes underlying addiction, in terms of neural systems, neurochemical basis, and molecular changes. Several types of addiction are discussed ranging from illicit drugs - cocaine, amphetamine, and heroin to legal drugs - alcohol and nicotine. In addition, it explores increasingly common behavioural
addictions such as gambling and obesity. Included are chapters on vulnerability to addiction, genetic factors, opponent motivational processes, animal models, relapse, cognitive deficits associated with
drug abuse, new pharmacological treatments, and current controversies concerning different neuropsychological theories of addiction. Throughout, it reports on cutting edge research using brain imaging, and state of the art molecular methodology.The book will make fascinating reading for students and teachers in the field of neuroscience, pharmacology and psychology, as well as experts in the field.
T. W. Robbins, B. J. Everitt and D. J. Nutt: Introduction. The
neurobiology of drug addiction: new vistas
G. F. Koob and M. Le Moal: Neurobiological mechanisms for opponent
motivational processes in addiction
B. J. Everitt, D. Belin, D. Economidou, Y. Pelloux, J. W. Dalley
and T. W. Robbins: Neural mechanisms underlying the vulnerability
to develop compulsive drug-seeking habits and addiction
T. E. Robinson and K. C. Berridge: The incentive sensitization
theory of addiction: some current issues
J. Stewart: Psychological and neural mechanisms of relapse
A. Markou: Neurobiology of nicotine dependence
D. N. Stephens and T. Duka: Cognitive and emotional consequences of
binge drinking: role of amygdala and prefrontal cortex
M. N. Potenza: The neurobiology of pathological gambling and drug
addiction: an overview and new findings
N. D. Volkow, G.-J. Wang, J. S. Fowler and F. Telang: Overlapping
neuronal circuits in addiction and obesity: evidence of systems
pathology
J. C. Crabbe: Neurogenetic studies of alcohol addiction
C. C. Y. Wong and G. Schumann: Genetics of addictions: strategies
for addressing heterogeneity and polygenicity of substance use
disorders
M. A. Nader, P. W. Czoty, R. W. Gould and N. V. Riddick: Positron
emission tomography imaging studies of dopamine receptors in
primate models of addiction
H. S. Crombag, J. M. Bossert, E. Koya and Y. Shaham:
Context-induced relapse to drug seeking: a review
E. J. Nestler: Transcriptional mechanisms of addiction: role of
changes in FosB
T. J. R. Beveridge, K. E. Gill, C. A. Hanlon and L. J. Porrino:
Parallel studies of cocaine-related neural and cognitive impairment
in humans and monkeys
H. Garavan, J. N. Kaufman and R. Hester: Acute effects of cocaine
on the neurobiology of cognitive control
C. P. O'Brien: Evidence-based treatments of addiction
Professor Robbins is Professor of Cognitive Neuroscience and Head
of the Department of Experimental Psychology at the University of
Cambridge. He is also Director of the Cambridge MRC-Wellcome Trust
Behavioural and Clinical Neuroscience Institute (BCNI), the main
objective of which is to inter-relate basic and clinical research
in psychiatry and neurology for such conditions as Parkinson's,
Huntington's, and Alzheimer's diseases, frontal lobe injury,
schizophrenia,
depression, drug addiction, and developmental syndromes such as
attention deficit/hyperactivity disorder. The BCNI has a particular
focus on pharmacological treatments in neuropsychiatry and
neurological disorders and how they actually work. Trevor has been
President of the European Behavioural Pharmacology Society
(1992-1994) and he won that Society's inaugural Distinguished
Achievement Award in 2001. He was also President of the British
Association of Psychopharmacology from 1996 to 1997. He a Fellow of
the Royal Society David is currently the Edmond J Safra Professor
of Neuropsychopharmacology and Head of the Department of
Neuropsychopharmacology and Molecular Imaging at
Imperial College London
He received his undergraduate training in medicine at Cambridge and
Guy's Hospital, and continued training in neurology to MRCP. After
completing his psychiatric training in Oxford, he continued there
as a lecturer and then later as a Wellcome Senior Fellow in
psychiatry. He then spent two years as Chief of the Section of
Clinical Science in the National Institute of Alcohol Abuse and
Alcoholism in NIH, Bethesda, USA. On returning to England in 1988
he set up the Psychopharmacology Unit in
Bristol, an interdisciplinary research grouping spanning the
departments of Psychiatry and Pharmacology. In December 2008 he
joined Imperial College London as the Edmond J Safra Chair in
Neuropsychopharmacology to concentrate on development of PET
imaging. Professor Everitt graduated in Zoology and Psychology at
Hull University, received a Ph.D. from the University of
Birmingham, and undertook post-doctoral research at Birmingham and
at the Karolinska Institute in Stockholm, with the eminent
neuroanatomists Tomas Hökfelt and Kjell Fuxe. He was appointed to
the Department of Anatomy at the University of Cambridge in 1974,
became a Fellow of Downing College in 1976, a
tenured University Lecturer and a Director of Studies in Medicine
at Downing in 1979. He has served on several national and
international advisory committees and has been President of the
British Association for
Psychopharmacology, the European Brain and Behaviour Society and
the European Behavioural Pharmacology Society. He is a Fellow of
the Royal Society (FRS), a Fellow of the Academy of Medical
Sciences (FMedSci), and has been awarded an Honorary D.Sc. by Hull
University
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