Based on the 38th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), held in Ascona, Switzerland in July 2010, this volume covers all aspects of oxygen transport from air to the cells, organs and organisms; instrumentation and methods to sense oxygen and clinical evidence.

1)      The History of ISOTT

Duane F. Bruley

Part 1: Brain Oxygenation

2)      Angioplasticity and Cerebrovascular Remodeling

Joseph C. LaManna

3)      Postoperative Cognitive Dysfunction and Cerebral Monitoring by Time-Resolved NIRS

Y. Kakihana, N. Okayama, A. Matsunaga, T. Yasuda, T. Imabayashi, M. Nakahara, N. Kiyonaga, K. Ikoma, T. Kikuchi, Y. Kanmura, M. Oda, E. Ohmae, T. Suzuki, Y. Yamashita, and M. Tamura

4)      Pulmonary Oxygen Uptake and Middle Cerebral Artery BFV during Cycling Exercise

Mikio Hiura, Norimitsu Kinoshita, Sigeki Izumi, Tadashi Nariai

5)      Colored Light and Brain and Muscle Oxygenation

J. Weinzirl, M. Wolf, M. Nelle, P. Heusserc, U. Wolf

6)      Influence of Myogenic and Metabolic Mechanism on Cerebral Autoregulation

Alexander Caicedo, Gunnar Naulaers, Martin Wolf, Petra Lemmers, Frank Van Bel, Lieveke Ameye, Sabine Van Huffel

7)      Frontal Cortex Activation during Electrical Muscle Stimulation

Makii Muthalib, Marco Ferrari, Valentina Quaresima, Kazunori Nosaka

8)      Cerebral Oxygen Saturation Measurements in Red Cell Transfusion

Zareen Bashir, Sarah Haynes, Peter Sandbach, Robin Calderwood, Charles McCollum, Maureen Thorniley

9)      Influence of Stress Preconditioning on Neurons in Rat Cerebral Ischemia

Takashi Eriguchi, Nobuo Kutsuna, Yuko Kondo, Jie Shi, Yoshihiro Murata, Hideki Oshima, Kaoru Sakatani, Yoichi Katayama

10)     Delta and Epsilon Protein Kinase C and Post-Ischemic Cerebral Blood Flow

Hung Wen Lin, David Della-Morte, John W. Thompson, Victoria L. Gresia, Srinivasan V. Narayanan, R. Anthony DeFazio, Ami P. Raval, Isabel Saul, Kunjan R. Dave, Kahlilia C. Morris, Min-Liang Si, Miguel Perez-Pinzon

11)     Cerebral Oxygenation in Infant on Extra-Corporeal Membrane Oxygenation

Maria D. Papademetriou, Ilias Tachtsidis, Murad Banaji, Martin J. Elliott, Aparna Hoskote, Clare E. Elwell

12)     Effects of Autonomic Nervous System on Neuroimaging: Vector Autoregressive Model

A. Seiyama, Y. Sasaki, A. Takatsuki, J. Seki

13)     Potential Effects of UMTS Electromagnetic Fields on Blood Circulation by NIRI

Sonja Spichtig, Felix Scholkmann, Lydia Chin, Hugo Lehmann, Martin Wolf

14)     Optical Diagnosis of Mental Stress: Review

Kaoru Sakatani

15)     Neuroprotective Properties of Ketone Bodies

Kui Xu, Joseph C. LaManna, Michelle A. Puchowicz

16)     Confounding Effect of Systemic Physiology on Hemodynamic Response in Newborns

B.B. Zimmermann, N. Roche-Labarbe, A. Surova, D.A. Boas, M. Wolf,  P.E. Grant, M.A. Franceschini

17)     How to Conduct Studies with Neonates combining NIRS and EEG

M. Biallas, I. Trajkovic, F. Scholkmann, C. Hagmann, M. Wolf

18)     Hybrid Optical Spectrometer Measures Oxidized Cytochrome c Oxidase and Scattering

Arnab Ghosh, Ilias Tachtsidis, Christina Kolyva, Chris E Cooper, Martin Smith, Clare E Elwell

Part 2: Tumor Oxygenation

19)     Isolated Hypoxic Liver Perfusion with Melfalan in Humans: Anesthesiologic Aspects

J.B. van den Bosch, C. Verhoef, F.L. Teng - van de Zande, J. Bakker, W. Erdmann, R. Tenbrinck

20)     Blood Flow and Oxygenation Status of Gastrointestinal Tumors

Peter Vaupel, Debra K. Kelleher

21)     Delayed Effects of Radiation on Mitochondrial DNA in Radiation-Sensitive Organs

Steven B Zhang, Mei Zhang, Yongbing Cao, Shanmin Yang, Amy P Zhang, Liangjie Yin, Yeping Tian, Kuzhong Zhang, Yangsong Guo, Xiaohui Wang, Chun Chen, Jun Ma, Deping Han, Alexandra Litvinchuk, Steven Swarts, Sadasivan Vidyasagar, David Maguire,  Lurong Zhang, Paul Okunieff

22)     Radiation-Induced Elevation of Plasma DNA in Mice is Associated with Genome

Lei Zhang, Mei Zhang, Bingrong Zhang, Yongbing Cao, Shanmin Yang, Liangjie Yin, Yeping Tian, Kunzhong Zhang, Lulu Zhang, Steven Swarts, Paul Okunieff, Lurong Zhang

23)     Could Multiple Myeloma VEGF modify the Systemic Microcirculation?

S. Cicco, P. Ditonno, A. Reale, S. Savino, A. Castrovilli, I. Catacchio, R. Ria,  A. Vacca

24)     Impact of Environmental Parameters on the Activity of the P-glycoprotein (Pgp)

Philipp Trach, Nuse Afahaene, Martin Nowak, Oliver Thews

25)     3-D High-Resolution Mapping of Mitochondrial Redox State of Human Breast Tumor

H. N. Xua, S. Niokab, B. Chanceb, L. Z. Lia

26)     Simultaneous Mapping of Mitochondrial Redox State and Glucose Uptake

H. N. Xu, G. Zheng, S. Nioka, B. Chance, L. Z. Li

Part 3: Anemia and Hypoxia

27)     Regulation of O2 Delivery by the Reaction of Nitrite with RBCs

Joseph M. Rifkind, Maria T. Salgado, Zeling Cao

28)     Clinical Applications of Tissue Oxygen Saturation Measurements

David K Harrison

29)     Cardiac Output in Hypoxia with Periodic Breathing and Constant PCO2

CB Wolff, M Bell, CD Thake, DJ Collier

30)     The Relationship of Acute Mountain Sickness to SaO2 at 3324 to 5176m

G Brierley, T Parks, CB Wolff

31)     Effects of Acute Anemia and Hyperoxia on Oxygen Distribution

Catalina Messmer, Pedro Cabrales, Marcos Intaglietta

Part 4: Oxygenation of various organs

32)     Monitoring Cardiopulmonary Function and Progression toward Shock: O2 Micro-sensor

David F. Wilson, Sergei A. Vinogradov, Gregory J. Schears, Tatiana V. Esipova, Anna Pastuszko

33)     Whole Body Oxygen Delivery and Consumption during Cardiopulmonary Bypass Surgery

J. Ashmore, J. Pickett, J. Alder, R. Marks, M. Thorniley

34)     Pharmacologic Interventions to Improve Splanchnic Oxygenation during Ventilation

A. Fournell, T.W.L. Scheeren, O. Picker, and L.A. Schwarte

35)     Effect of Pneumoperitoneum on Functional Residual Capacity

Akira Matsunaga, Katsuhiro Ohse, Yasuyuki Kakihana, Mina Masuda, Kanako Ikoma, Yuichi Kanmura

36)     Molecular H2 Consumption in Human Whole Body after Ingestion of H2-Rich Water

Akito Shimouchi, Kazutoshi Nose, Mikiyasu Shirai, Takaharu Kondo

37)     Prenylated Acylphloroglucinol Derivatives

Ryo Tanaka, Yoshihiro Uto, Kenta Ohnaka, Yuki Ohta, Kazufumi Yazaki, Naoyuki Umemoto, Eiji Nakata, Hitoshi Hori

Part 5: Muscle Oxygenation

38)     Retrograde Perfusion in Diabetics Suffering from Arteriosclerosis Obliterans

Tomiyasu Koyama, Tadahiro Sasajima

39)     Triplet Imaging of O2 Consumption in a Single Smooth Muscle Cell

Matthias Geissbuehler, Thiemo Spielmann, Aurélie Formey, Iwan Märki, Marcel Leutenegger, Boris Hinz, Kai Johnsson, Dimitri Van De Ville, Theo Lasser

40)     Submaximal Handgrip Muscle Force and NIRS-measured Motor Cortical Activation

Gérard Derosiere, Stéphane Perrey

Part 6: Methodology for O2 measurement

41)     Oxygenation in a Deep Blood Vessel Measured by  Acousto-optics and Microbubbles

Jack E. Honeysett, Eleanor Stride, Terence S. Leung

42)     Sensitivity Enhancement of NIR Fluorescence Contrast Agent by Gold Nanoparticles

Kyung A. Kang, Jianting Wang, Martin G. O'Toole, Michael Nantz, Joseph D. Moore, Sebastien Laulhe, Samuel Achilefu

43)     Model to Aid NIRS Data Interpretation: Results from a Hypercapnia Study

Tracy Moroz, Murad Banaji, Martin Tisdall, Chris E. Cooper, Clare E. Elwell, Ilias Tachtsidis

44)     Boron Tracedrug: a Next-generation Drug Model

Eiji Nakata, Masato Koizumi, Yohei Yamashita, Yoshihiro Uto, Hitoshi Hori

45)     Modelling Physiological Oscillations of NIRS by Time-Varying Fourier Series